CAFA 6 (Critical Assessment of Function Annotation 6)
6th iteration of the CAFA community challenge for protein function prediction on Kaggle. Predicts Gene Ontology terms (molecular function, biological process, cellular component) from amino acid sequences. Evaluated against experimentally validated annotations accumulated post-deadline.
Composite
97.5
Experimental validation
Wet-lab confirmed
Stages
Target ID
Modalities
protein_sequence
Task types
function_predictiongene_ontology
Size
description: GO annotations
License
Competition
First release
2025-01
Last updated
2026-05
Official site
Leaderboard
Dataset
Code / GitHub
→ repository
HuggingFace
→ HF
Paper
CAFA 6: Critical Assessment of Functional Annotation · · 2025 · 5 citations
Flags
competitionkaggletime_delayed_evaluation
Experts
—
Groups
—
Hosted by
—
Related benchmarks
Rubric (7-criterion)
rigor
5
coverage
5
maintenance
5
adoption
5
quality
5
accessibility
5
industry_relevance
4
Notes
Continuation of CAFA series (since 2010). Time-delayed evaluation prevents data leakage. Final evaluation May 2026 using annotations from UniProt Dec 2025/Jan 2026. Second iteration hosted on Kaggle.