Biologics
🧬 Benchmarks for biologics — antibodies, peptides, proteins, ADCs, bispecifics, and related modalities.
42
Benchmarks
88
Avg composite score
14
Wet-lab / prospective validated
9
Pipeline stages covered
Stage distribution
Virtual Cell (1)Disease Modeling (1)Target ID (9)Hit ID (28)Lead ID / ADMET (15)Developmental Candidate (6)IND-enabling (5)Post-market / RWE (1)
Validation distribution
Wet-lab confirmed (13)
Prospective (1)
Retrospective (26)
None (2)
All Biologics benchmarks (42)
| # | Benchmark | Stages | Validation | Score | Flags |
|---|---|---|---|---|---|
| 1 | SAbDab | Hit IDLead ID / ADMETDevelopmental Candidate | Retrospective | 100.0 | |
| 2 | Protein Language Model Eval 2026 | Virtual CellHit ID | Wet-lab confirmed | 100.0 | |
| 3 | ChEMBL | Hit IDLead ID / ADMET | Wet-lab confirmed | 97.5 | |
| 4 | Observed Antibody Space (OAS) | Hit IDLead ID / ADMET | Retrospective | 97.5 | |
| 5 | ProteinGym | Target IDLead ID / ADMETIND-enabling | Wet-lab confirmed | 97.5 | |
| 6 | CAFA 6 (Critical Assessment of Function Annotation 6) | Target ID | Wet-lab confirmed | 97.5 | competitionkaggletime_delayed_evaluation |
| 7 | PoseBusters | Hit ID | Retrospective | 97.0 | |
| 8 | PLINDER | Hit ID | Retrospective | 97.0 | |
| 9 | PLINDER v2 Protein-Ligand Benchmark | Hit ID | Retrospective | 97.0 | |
| 10 | Therapeutic Antibody Design Benchmark 2026 | Hit IDLead ID / ADMET | Wet-lab confirmed | 97.0 | |
| 11 | Protein Design Benchmark 2026 | Hit ID | Wet-lab confirmed | 97.0 | |
| 12 | STRING | Target IDDisease Modeling | Retrospective | 94.9 | |
| 13 | CASP15 | Hit IDTarget ID | Retrospective | 94.9 | |
| 14 | CASP16 | Hit ID | Retrospective | 94.4 | |
| 15 | CAMEO weekly targets | Hit ID | Retrospective | 94.4 | |
| 16 | Boltz-1 Structure Prediction Benchmark | Hit ID | Retrospective | 94.4 | |
| 17 | FLAb2 (Fitness Landscape for Antibodies 2) | IND-enablingLead ID / ADMET | Wet-lab confirmed | 91.9 | biologicsmulti_property |
| 18 | PoseX (Protein-Ligand Docking Benchmark) | Hit IDLead ID / ADMET | Retrospective | 91.4 | leakage_preventioncross_dockingleaderboard |
| 19 | FAERS (raw) | Post-market / RWE | Retrospective | 91.1 | |
| 20 | canSAR | Target IDHit ID | Wet-lab confirmed | 89.4 | |
| 21 | PINDER | Hit ID | Retrospective | 88.9 | |
| 22 | CoV-AbDab | Hit ID | Retrospective | 88.9 | |
| 23 | BenchBB (Bench-tested Binder Benchmark) | Hit IDLead ID / ADMET | Wet-lab confirmed | 88.4 | experimental_validationcompetitionwet_lab |
| 24 | ISM Benchmarks: GPCRs (Insilico) | Hit IDLead ID / ADMET | Retrospective | 87.6 | |
| 25 | CAPRI Rounds | Hit ID | Retrospective | 86.3 | |
| 26 | OpenBind EV-A71 Structure-Affinity Dataset | Hit IDLead ID / ADMET | Wet-lab confirmed | 84.8 | experimental_validationcrystallography |
| 27 | CAFA5 | Target ID | Retrospective | 84.3 | |
| 28 | LSD Large-Scale Docking Database | Hit ID | Wet-lab confirmed | 82.5 | ultra_large_scaleexperimental_validation |
| 29 | CycPeptMPDB (Cyclic Peptide Membrane Permeability Database) | IND-enablingLead ID / ADMET | Wet-lab confirmed | 82.5 | biologicspeptide_therapeuticspermeability |
| 30 | FLIP | Target IDDevelopmental Candidate | Retrospective | 80.8 | |
| 31 | AbBiBench (Antibody Binding Benchmark) | Lead ID / ADMET | Retrospective | 80.8 | biologicsaffinity_maturation |
| 32 | Open Systems Pharmacology / PK-Sim | phase-iIND-enabling | Retrospective | 80.3 | |
| 33 | pepADMET | IND-enablingLead ID / ADMET | Retrospective | 80.0 | biologicspeptide_therapeuticsfirst_in_class |
| 34 | Polaris Biologics (Polyreactivity / SEC / Tm) | Developmental Candidate | Prospective | 79.0 | |
| 35 | BioDesignBench | Hit IDLead ID / ADMET | Retrospective | 77.7 | agent_benchmarkprotein_engineering |
| 36 | IgLM / AntiBERTa benchmarks | Hit IDDevelopmental Candidate | Wet-lab confirmed | 77.5 | |
| 37 | CASF-2016 | Hit ID | Retrospective | 76.2 | |
| 38 | PDBbind | Hit IDLead ID / ADMET | Retrospective | 75.9 | data-leakage-known |
| 39 | TAPE | Target IDDevelopmental Candidate | Retrospective | 74.9 | deprecated-recommend-replace |
| 40 | PEER | Target IDDevelopmental Candidate | Retrospective | 74.4 | |
| 41 | PDFBench (De Novo Protein Design from Function) | Hit ID | None | 68.9 | text_guided_designmulti_metric |
| 42 | VSDS-vd (Virtual Screening Decoy Set for Docking) | Hit ID | None | 65.8 | chinese_benchmarkvirtual_screening |