ISM Benchmarks: GPCRs (Insilico)
87-benchmark GPCR affinity suite on ScienceAIBench / InsilicoBench / DDB — kinome-scale coverage of class A/B/C GPCRs.
Composite score: 87.6
Rubric (1–5 per criterion)
rigor
4/5
coverage
5/5
maintenance
5/5
adoption
3/5
quality
4/5
accessibility
5/5
industry_relevance
5/5
Metadata
Stages
Hit IDLead ID / ADMET
Modalities
small-moleculeprotein-general
Task types
binding-affinity
License
CC-BY
First release
2025-02
Last updated
2026-04
Flags
none
Size & scope
- benchmarks: 87
- gpcr_targets: 87
Primary paper
Title
GPCR affinity benchmark methodology
Authors
I, n, s, i, l, i, c, o, , A, I, , T, e, a, m
Year
2025
DOI / arXiv
N/A — portal
Citations
8
Links
- Official site: https://scienceaibench.insilico.com/
- GitHub: N/A
- Leaderboard: https://scienceaibench.insilico.com/
Hosted by (initiatives)
Experts (primary authors / maintainers)
Groups (host labs / companies / consortia)
Related benchmarks
Notes (honest caveats)
Largest open GPCR affinity benchmark. Leaderboards test external frontier LLMs — not self-referential.