Protein Design Benchmark 2026
Standardized evaluation of de novo binder design (RFdiffusion, Chroma, ESM-IF) with wet-lab Kd measurement on 8 targets.
Composite
97.0
Experimental validation
Wet-lab confirmed
Stages
Hit ID
Modalities
biologic
Task types
binder-designstructure-guided-generation
Size
designs: 43,000
targets: 8
targets: 8
License
MIT
First release
2026-01
Last updated
2026-04
Official site
Leaderboard
Dataset
→ dataset
Code / GitHub
HuggingFace
→ HF
Paper
Benchmarking de novo binder design 2026 · Baker D, Ovchinnikov S · 2026 · paper · doi:10.1126/science.ade5026 · 95 citations
Flags
none
Experts
—
Groups
—
Hosted by
—
Related benchmarks
Rubric (7-criterion)
rigor
5
coverage
4
maintenance
5
adoption
5
quality
5
accessibility
5
industry_relevance
5
Notes
All submitted designs characterized in IPD / external wet labs.