BenchBB (Bench-tested Binder Benchmark)
Curated set of 7 standardized protein targets for benchmarking computational binder design methods with wet-lab validation. From Adaptyv Bio. Provides consistent antigen targets for fair cross-method comparison with experimental testing infrastructure.
Composite
88.4
Experimental validation
Wet-lab confirmed
Stages
Hit IDLead ID / ADMET
Modalities
protein_structureprotein_sequence
Task types
protein_designbinding_predictionexperimental_validation
Size
antigen_targets: 7
description: standardized assays
description: standardized assays
License
Open
First release
2025-04
Last updated
2025-10
Official site
Leaderboard
Dataset
→ dataset
Code / GitHub
→ repository
HuggingFace
→ HF
Paper
Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition · · 2025 · paper · doi:10.1101/2025.04.17.648362 · 12 citations
Flags
experimental_validationcompetitionwet_lab
Experts
—
Groups
—
Hosted by
—
Related benchmarks
Rubric (7-criterion)
rigor
5
coverage
3
maintenance
5
adoption
4
quality
5
accessibility
4
industry_relevance
5
Notes
Unique in providing actual wet-lab validation infrastructure. Adaptyv runs cloud lab for protein designers. EGFR competition attracted diverse computational methods. Boolean Biotech VHH Competition 2025 adopted BenchBB targets. Drives real experimental iteration.