Cell Line Sensitivity Benchmark (CLSB)

Cell line drug-sensitivity prediction across GDSC2, CCLE, and PRISM with standardized splits and matched molecular features.

Composite

88.1

Experimental validation

Wet-lab confirmed

Stages

Target IDLead ID / ADMET

Modalities

small-molecule

Task types

sensitivity-prediction

Size

cell_lines: 1,850
compounds: 4,500

License

CC-BY-4.0

First release

2025-07

Last updated

2026-03

Official site

→ project page

Leaderboard

→ leaderboard

Dataset

→ dataset

Code / GitHub

→ repository

HuggingFace

→ HF

Paper

Cell Line Sensitivity Benchmark 2025 · Theodoris CV, et al. · 2025 · paper · doi:10.1038/s41587-025-02015-5 · 52 citations

Flags

none

Experts

—

Groups

Broad Institute

Hosted by

—

Related benchmarks

DepMap (Cancer Dependency Map), TDC DrugSyn (OncoPolyPharm + DrugComb_NCI60)

Rubric (7-criterion)

rigor

coverage

maintenance

adoption

quality

accessibility

industry_relevance

Notes

DepMap-adjacent but adds new splits and PRISM v4.

← Back to all benchmarks

Compare:

Open comparison →