CRISPR Outcome Prediction Benchmark

Benchmark for CRISPR guide design and edit-outcome prediction across Cas9, Cas12a, prime editing, base editing.

Composite
79.5
Experimental validation
Wet-lab confirmed
Stages
Hit ID
Modalities
gene-therapy
Task types
edit-outcome-predictionoff-target-prediction
Size
guides: 220,000
cell_lines: 17
License
MIT
First release
2025-06
Last updated
2026-02
Official site
→ project page
Leaderboard
→ leaderboard
Dataset
→ dataset
Code / GitHub
→ repository
HuggingFace
→ HF
Paper
Benchmarking CRISPR outcome prediction · Leenay R, Pinello L · 2025 · paper · doi:10.1038/s41551-025-01201-3 · 46 citations
Flags
none
Experts
Groups
Hosted by
Therapeutics Data Commons (TDC)
Related benchmarks

Rubric (7-criterion)

rigor
4
coverage
4
maintenance
4
adoption
3
quality
4
accessibility
5
industry_relevance
4

Notes

Prospective track added in Q1 2026.

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