DrugComb 2.0 Synergy Benchmark

Expanded DrugComb with 14M drug-drug-cell combinations; robust splits for zero-shot cell-line transfer.

Composite
83.0
Experimental validation
Retrospective
Stages
Lead ID / ADMETDevelopmental Candidate
Modalities
small-molecule
Task types
synergy-prediction
Size
combinations: 14,000,000
cell_lines: 125
License
CC-BY-NC-4.0
First release
2025-01
Last updated
2026-03
Official site
→ project page
Leaderboard
→ leaderboard
Dataset
→ dataset
Code / GitHub
→ repository
HuggingFace
→ HF
Paper
DrugComb 2.0: a benchmark for drug synergy prediction · Zagidullin B, et al. · 2025 · paper · doi:10.1093/nar/gkab1058 · 280 citations
Flags
none
Experts
Groups
Hosted by
Therapeutics Data Commons (TDC)
Related benchmarks
TDC DrugSyn (OncoPolyPharm + DrugComb_NCI60)

Rubric (7-criterion)

rigor
4
coverage
5
maintenance
4
adoption
4
quality
4
accessibility
4
industry_relevance
4

Notes

Industry-relevant for combination oncology.

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