Longevity Compound Benchmark

Benchmark for predicting geroprotective activity from compound structure and cellular signatures. Curated against DrugAge + published lifespan extension studies.

Composite
84.6
Experimental validation
Wet-lab confirmed
Stages
Hit IDLead ID / ADMET
Modalities
small-molecule
Task types
geroprotective-activitylifespan-extension-prediction
Size
compounds: 1,820
License
CC-BY-4.0
First release
2026-02
Last updated
2026-04
Official site
→ project page
Leaderboard
→ leaderboard
Dataset
→ dataset
Code / GitHub
→ repository
HuggingFace
→ HF
Paper
Longevity Compound Benchmark 2026 · Aliper A, Zhavoronkov A · 2026 · paper · doi:10.1038/s43587-026-00401-x · 24 citations
Flags
none
Experts
Groups
Insilico Medicine
Hosted by
ScienceAIBench
Related benchmarks
Longevity Benchmark (Insilico)

Rubric (7-criterion)

rigor
4
coverage
4
maintenance
5
adoption
3
quality
4
accessibility
5
industry_relevance
5

Notes

Insilico-hosted; unique in bridging cheminformatics and aging biology.

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