LINCS L1000 / CMap
1.3M transcriptional profiles across 978 landmark genes after genetic or chemical perturbations.
Composite score: 89.9
Rubric (1–5 per criterion)
rigor
5/5
coverage
5/5
maintenance
3/5
adoption
5/5
quality
4/5
accessibility
4/5
industry_relevance
5/5
Metadata
Stages
Virtual CellDisease ModelingTarget ID
Modalities
small-moleculecross-modality
Task types
signature-matchmechanism-of-action
License
CC-BY
First release
2017-11
Last updated
2024-03
Flags
none
Size & scope
- profiles: 1319138
- compounds: 33000
- cell_lines: 82
Primary paper
Title
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Authors
Subramanian A, Narayan R, Corsello SM, et al.
Year
2017
DOI / arXiv
Citations
3700
Links
- Official site: https://clue.io/
- GitHub: https://github.com/cmap
- Leaderboard: N/A
Hosted by (initiatives)
- not hosted by any tracked initiative
Experts (primary authors / maintainers)
Groups (host labs / companies / consortia)
Related benchmarks
Notes (honest caveats)
Foundational pharma resource for MoA work. Batch effects require careful handling.