Open Problems: Perturbation Prediction
NeurIPS competition & continuing benchmark for single-cell perturbation response prediction under distribution shift.
Composite score: 91.9
Rubric (1–5 per criterion)
rigor
5/5
coverage
5/5
maintenance
5/5
adoption
4/5
quality
5/5
accessibility
5/5
industry_relevance
3/5
Metadata
Stages
Virtual Cell
Modalities
cross-modality
Task types
perturbation-prediction
License
MIT
First release
2021-06
Last updated
2024-12
Flags
none
Size & scope
- cells: 240000
- perturbations: 144
Primary paper
Title
Predicting Cellular Responses to Novel Drug Perturbations at a Single-Cell Resolution
Authors
Hetzel L, Boehm S, Kilbertus N, et al.
Year
2022
DOI / arXiv
Citations
180
Links
- Official site: https://openproblems.bio/
- GitHub: https://github.com/openproblems-bio/openproblems
- Leaderboard: https://openproblems.bio/results
Hosted by (initiatives)
Experts (primary authors / maintainers)
Groups (host labs / companies / consortia)
Related benchmarks
Notes (honest caveats)
Best-in-class rigor (Viash workflow, hidden test, NeurIPS track).