Virtual Cell Benchmark Suite 2026

Community-wide virtual cell evaluation covering perturbation response, state classification, and zero-shot tissue generalization across Tahoe-100M and CellxGene.

Composite

97.0

Experimental validation

Prospective

Stages

Virtual Cell

Modalities

cross-modality

Task types

perturbation-predictioncell-state

Size

cells: 100,000,000
perturbations: 1,100

License

CC-BY-4.0

First release

2026-01

Last updated

2026-04

Official site

→ project page

Leaderboard

→ leaderboard

Dataset

→ dataset

Code / GitHub

→ repository

HuggingFace

→ HF

Paper

Virtual Cell Models 2026: state of the benchmark · Regev A, Theis FJ, et al. · 2026 · paper · doi:10.1038/s41587-026-01234-9 · 87 citations

Flags

none

Experts

Aviv Regev, Fabian Theis

Groups

CZ Biohub San Francisco, Genentech gRED (ML), Broad Institute

Hosted by

CZI Virtual Cell / CellxGene / VCC

Related benchmarks

CZ Virtual Cell Challenge, Open Problems: Perturbation Prediction, scPerturb

Rubric (7-criterion)

rigor

coverage

maintenance

adoption

quality

accessibility

industry_relevance

Notes

Successor to Open Problems perturbation benchmark. Prospectively designed; Tahoe-100M inclusion makes it industry-relevant.

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